Finely chop the salmon fillets into small pieces.
In a large bowl, combine the chopped salmon, breadcrumbs, mayonnaise, Dijon mustard, lemon juice, garlic powder, salt, and pepper.
Mix until the ingredients are evenly incorporated.
Divide the mixture into 4 to 6 equal portions and shape them into burger patties.
Heat a lightly greased skillet or grill over medium heat.
Cook the patties for 4–5 minutes per side, or until golden brown and the salmon is fully cooked.
Toast the burger buns if desired.
Assemble each Tangy Salmon Burger with lettuce, tomato slices, and your favorite toppings.
Serve immediately while warm.