Preheat the oven to 400°F (200°C).
Pat the tilapia fillets dry with paper towels.
Season both sides with salt, black pepper, paprika, thyme, and oregano.
Arrange the fillets in a lightly greased 9×13-inch baking dish.
In a small bowl, whisk together the melted butter, minced garlic, lemon juice, and lemon zest.
Pour the garlic butter mixture evenly over the fish, making sure each fillet is coated.
Bake the Garlic Butter Oven Baked Tilapia for 10–12 minutes, or until the fish flakes easily with a fork.
Garnish with fresh parsley, red pepper flakes, and lemon slices before serving.
Serve immediately with your favorite side dishes.