Preheat your oven to 375°F (190°C).
In a medium mixing bowl, combine the crab meat, chopped shrimp, softened cream cheese, breadcrumbs, lemon juice, parsley, garlic powder, salt, and black pepper until evenly mixed.
Carefully cut a deep pocket into the side of each salmon fillet without slicing all the way through.
Spoon the seafood mixture evenly into each salmon pocket.
Heat a large skillet over medium heat and add a drizzle of olive oil.
Sear the stuffed salmon for 3–4 minutes per side until lightly golden.
Transfer the fillets to a baking dish.
Bake for 15 minutes, or until the Crab & Shrimp Stuffed Salmon reaches an internal temperature of 145°F (63°C) and flakes easily with a fork.
Garnish with fresh parsley and serve immediately with lemon wedges if desired.