In a large bowl, season the salmon cubes with kosher salt, black pepper, and olive oil. Mix well to coat evenly.
In a shallow plate, combine panko breadcrumbs, Italian seasoning, garlic powder, onion powder, and a pinch of salt and pepper.
Dip each salmon piece into the breadcrumb mixture, coating all sides evenly. Place on a tray.
Preheat the air fryer to 375°F (190°C).
Arrange the breaded salmon in a single layer in the air fryer basket without overlapping.
Cook Air Fryer Salmon Bites for 8 minutes, shaking the basket halfway through for even crisping.
Meanwhile, mix honey, hot sauce, and soy sauce in a small bowl.
Once cooked, drizzle the sauce over the salmon bites and gently toss to coat.